This pathway maintains cell survival in the context of autophagy associated with infection and is distinct from autophagic cell death. The potential therapeutic use of modulating this pathway is ...

近日，卢曾军教授课题组在《PLOS PATHOGENS》期刊上发表了题为“Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the ...

Both PINK1 and Parkin might, therefore, be integral components in the autophagic degradation of defective mitochondria. To test this hypothesis, Youle's team conducted standard laboratory tests ...

The research team plans to further explore drug developments that can enhance the autophagic function of astrocytes to prevent or alleviate dementia symptoms, and to conduct preclinical studies in ...

Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key ...

Not only have researchers identified how a common cellular protein affects aging, but they’ve tweaked the genes that produce ...

1.Watanabe T, Seki T, Fukano T, Sakaue-Sawano A, Karasawa S, Kubota M, Kurokawa H, Inoue K, Akatsuka J, Miyawaki A.: "Genetic visualization of protein interactions ...

Autophagy implicates in a variety of biological processes and disease developments. We developed Bioluminescence Resonance Energy Transfer (BRET)-based high throughput chemical screening to regulate ...

Because nitrogen fertilizers contribute to global greenhouse gas emissions, scientists are looking for ways to modify ...

Heat shock protein 90 (HSP90) is a molecular chaperone that promotes the proper folding and stability of several oncogenic ...

This useful study examines the function of the rnc gene, which encodes the RNase III ribonuclease, as it relates to virulence of Salmonella Enteritidis. The authors demonstrate that the rnc gene is ...