The topic we propose for this Frontiers Research Topic in Microbiology covers the broad theme of “vaccines against antigenically variable viruses”. Viruses that have numerous serotypes or strains are ...

More information: Alpha Forna et al, Sequence-based detection of emerging antigenically novel influenza A viruses, ...

This technology employs protein engineering to stabilize S in its prefusion conformation, preventing structural rearrangement, and exposing antigenically preferable surfaces. The technology has ...

A Vero-cell-culture–derived trivalent influenza vaccine had a protective efficacy of 79% against antigenically matched influenza strains. Conventional egg-based influenza vaccines have several ...

Duke researchers have opened a new avenue in the attack against influenza viruses by creating a vaccine that encourages the immune system to target a portion of the virus surface that is less variable ...

A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A ...

As one of the main influenza antigens, neuraminidase (NA) in H3N2 virus has evolved extensively for more than 50 years due to continuous immune pressure. While NA has recently emerged as an effective ...

ALA = Amoebic liver abscess; Eh = Entamoeba histolytica; EhCP = E. histolytica cysteine proteinase; Ehserp = E. histolytica serine proteinase; EhSTIRP = Serine threonine isoleucine-rich protein ...

The complex and ever-evolving immunity landscape associated with SARS-CoV-2, combined with immune evasion by omicron ...

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Figure 3 Screening for immunogenic epitopes. A summary of enzyme-linked immunospot (ELISpot), intracellular cytokine staining (ICS) and activation-induced marker (AIM) assay protocols for validating ...