Distinct helper T cell subsets are now known to be primed by different types of antigen presenting cells (APCs), and antigen presentation by atypical/non-professional cells is an area of intense ...

Antigen processing and presentation is the process by which protein antigen is ingested by an antigen-presenting cell (APC), partially digested into peptide fragments and then displayed on the ...

Nevertheless, MHC presentation of neoantigens is not random but follows certain rules, and the efficiency of neoantigen detection may be further improved with technological innovations. In this review ...

To enable robust biochemical experimentation in cardiac fibroblasts we immortalized human cardiac fibroblasts using lentiviral delivered SV40 large T antigen (SV40), human telomerase reverse ...

Thus, TLR control of antigen presentation favours the presentation of microbial antigens within the context of T-lymphocyte costimulatory molecule expression. This current work aims to identify ...

Objectives Myofibroblasts are key effector cells in the extracellular matrix remodelling of systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of fibroblast ...

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There is a critical need for therapies that specifically target activated cardiac fibroblasts to mitigate these adverse effects. Recent advances have shown that chimeric antigen receptor (CAR)-T cells ...

Background Peritoneal metastasis is the most common metastasis pattern of gastric cancer. Patients with gastric cancer ...

Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery. Results Gemcitabine accumulation was significantly enhanced in fibroblast-rich tumours ...

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