The allele frequency represents the incidence of a gene variant in a population. Alleles are variant forms of a gene that are located at the same position, or genetic locus, on a chromosome.

Current techniques have their roots in allele-specific oligonucleotide hybridization (ASOH) 1. In its basic form (i.e., hybridization, stringent washing, and signal detection), ASOH is limited by ...

A fatal, highly hereditary illness with no disease-modifying treatments, Huntington’s is long overdue for a therapeutic win.

"I think in medicine, just like in society, we see death as a failure -- and we do everything we can to avoid failure." -- ...

The association between the HLA-DRB1*01:03 allele and ulcerative colitis has been noted previously, but there is a clinical need for biomarkers that could identify which patients are more likely ...

休斯顿 - 专注于调节性T细胞疗法的生物技术公司Coya Therapeutics, Inc.

The past four years have brought disappointment for the Huntington’s community, but optimism is growing as companies ...

The HLA-DRB1*01:03 allele explained this association overall (OR 3.32, 95% CI 2.25-4.89, P=1.45 × 10-9) and in the two ...

An ancient gene mutation among First Nations inhabitants of Oceania may make them more susceptible to infectious diseases ...

Researchers have discovered that a gene variant, KIR3DL1*114, linked to Denisovans, may impact the immune response in First ...

The study identifies links between gut microbiota, genetic variants in IBD, and mental health disorders, offering insights ...

Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...