一氧化氮（NO）曾普遍被视为一种有毒有害气体，应尽可能远离。然而，后来的科学研究揭示它在生物体内发挥极为重要的生理作用，NO ...

A potential mediator of migraine pathogenesis is the signaling molecule pituitary adenylate cyclase–activating polypeptide (PACAP). 5 Experimental studies have shown that intravenous infusion of ...

In the first step, nucleophilic attack on the alpha-phosphorus of ATP (adenosine triphosphate) or NAD + (nicotinamide adenine dinucleotide) by ligase results in release of pyrophosphate or NMN ...

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

The migraine market across the 7MM is poised to grow at a compound annual growth rate (CAGR) of 6.0% from $9.2bn in 2023 to ...

In secondary headache, the pain is a symptom of an underlying disorder. Pituitary adenylate cyclase-activating polypeptide signalling has been linked to migraine pathogenesis. In this Review ...

Tom Nolan reviews this week’s research You never have to wait too long for a trial of a new drug for migraine. The latest one is Lu AG09222, a monoclonal antibody to pituitary adenylate ...

One of the biochemical systems that produces ATP is the essential enzyme adenylate kinase, which catalyzes the production of ATP from the building blocks ADP and AMP. The enzyme is dependent on ...

ATP-dependent RNA ligases join 3’-OH and 5’-PO 4 RNA termini via three nucleotidyl transfer steps similar to those of DNA ligases: (Step 1) ligase reacts with ATP to form a covalent ...

However, the cellular mechanisms by which MC4R regulates reproduction are unknown. Kiss1 neurons directly stimulate gonadotropin-releasing hormone (GnRH) release through two distinct populations; the ...