Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the ...

The processing of self-peptides in TECs depends on bulk protein degradation systems, specifically autophagy and proteasomes. Studies using autophagy- and proteasome-deficient mouse models have ...

Department of Microbiology & Cell Biology, Indian Institute of Science, India Centre of Infectious Disease Research, Indian Institute of Science, Bangalore, India Pharmacology Division, CSIR-Central ...

Michael Boyle is an experienced financial professional with more than 10 years working with financial planning, derivatives, equities, fixed income, project management, and analytics. Suzanne is a ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Pre-clinical experimental studies have demonstrated that pharmacological activation of AMPK can offer multiple potential benefits during sepsis, including anti-inflammatory effects, induction of ...

Drink green tea and eat broccoli, oranges and berries “AMPK is often seen as the ‘master switch’ of our metabolism and ... Studies dating back more than a decade show that it activates autophagy – the ...

Insulin resistance disrupts muscle cell growth pathways, while hyperinsulinemia and lipotoxicity inhibit crucial recovery processes like autophagy and protein metabolism ... Moreover, the compromised ...

Obesity has nearly tripled worldwide since the 1970s. A major health concern related to obesity is that excess fat can spill into organs such as the liver. This can lead to fatty liver disease or even ...