followed by internalization of the virus into the cell and the subsequent uncoating of the virion to release the transcriptionally active particle. These events are essential for the successful ...

The formation of clathrin coats is more complicated, as coat assembly, vesicle budding and uncoating are distinguishable steps regulated by different sets of proteins. Adaptor proteins (AP1 ...

This ‘uncoating step’ is essential in order for internalized surface vesicles and their associated proteins to be routed deeper into the cell through the endocytic pathway. We are currently ...

1). In a poorly understood process referred to as ‘uncoating’, the core undergoes re-organization to form a reverse transcription complex (RTC). This complex differs compositionally from the ...

Drugs that require a more acidic environment for absorption, uncoating, or activation and drugs that rely on intestinal transporters located in the duodenum for proper absorption would be most ...

The small GTPase, rab5, regulates many events on the early endocytic pathway including cargo selection, vesicle uncoating, endosomal fusion, and signalling. Guanine nucleotide exchange factors (GEFs) ...

Click here for the Yamauchi lab website. Current research interests: Cell biology of human virus entry into host cells, mehanism of virus uncoating and assembly Discovery of antivirals against viruses ...