Sea's novel synthetic molecules act at the neurotransmitter glutamate pathway on two clinically validated targets in the central nervous system, "the CNS"Two potent, selective, pre-clinical stage ...

This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic ...

Efficient DNA transfection is critical for biological research and new clinical therapies, but the mechanisms responsible for DNA uptake are unknown. Current nonviral transfection methods ...

Researchers have developed a novel delivery system for sending CRISPR reagents to brain cells, where it performs its gene ...

The study revealed that more than 60% of the neurons in the hippocampus and 40% of neurons in the cortex were transfected. "This is a very promising method for genetic conditions affecting the ...

Introduction to HEK 293 Cells HEK 293 cells, also known as Human Embryonic Kidney 293 cells, have become a crucial tool in ...

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

Electrophysiological and cell biological studies were employed to characterise the effects on ion transport both in patient respiratory epithelial cells and in transfected HEK293 cells. Results The ...

PDX-1 is a critically important transcription factor for the insulin promoter, is absent in glucotoxic islets, and, when transfected into glucotoxic ß-cells, improves insulin promoter activity.

The study revealed that more than 60% of the neurons in the hippocampus and 40% of neurons in the cortex were transfected. "This is a very promising method for genetic conditions affecting the ...

The study revealed that more than 60% of the neurons in the hippocampus and 40% of neurons in the cortex were transfected. “This is a very promising method for genetic conditions affecting the central ...