Bronopol affected 3.4% of patch test patients in 2005–2006 (Zug et al., 2009). This preservative has activity against gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa.
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An assortment of different preservative formulations has been used in ophthalmic medicines and many of these preservatives have been linked to unwanted ocular surface side effects. Benzalkonium ...