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Researchers developed a highly selective fluorescent probe to image serotonin in cells and animal models, shedding light on ...

Serotonin in depression is highly relevant in diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a fluorescent probe for imaging processes that is ...

Afterward, facilitated by proximity, a second bond is formed (nucleophilic reaction between an amino group in serotonin and a ...

Serotonin in depression is highly relevant in diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a fluorescent probe for imaging processes that is ...

For example, alcohols can undergo nucleophilic displacements of the hydroxyl functionality, carboxaldehydes can participate in condensations with primary amines to form enamines and carboxylic ...

"We also focused on cysteine because it's the most nucleophilic amino acid," says first author Evert Njomen, Ph.D., an HHMI Hanna H. Gray Fellow at Scripps Research and a postdoctoral research ...

High-intensity ultrasound initiates formal retro-[2+2] cycloaddition by stretching a benzocyclobutene core from strategically placed anchor points ...

Cancer Res 1 September 1963; 23 (8_Part_1): 1315–1333. The term “alkylating agent” has been defined and a detailed discussion made of the mechanisms (Sn1 and Sn2) by which they interact with ...

"We also focused on cysteine because it's the most nucleophilic amino acid," says first author Evert Njomen, PhD, an HHMI Hanna H. Gray Fellow at Scripps Research and a postdoctoral research ...

In the original Barton publication [3] the reaction was optimized by using a strong guanidine base, the inverse addition of the hydrazone to an iodine solution, and by exclusion of water.

The classic Claisen condensation, a self-condensation between two molecules of a compound containing an enolizable ester. The mixed (or "crossed") Claisen condensation, where one enolizable ester or ...