In this discovery-oriented project, the Tissue Repair and Mechanobiology Laboratory is using screening approaches including RNA interference, RNA and assay for transposase-accessible chromatin (ATAC) ...

Idiopathic pulmonary fibrosis is a chronic, progressive, incurable lung disease, leading to irreversible lung tissue ...

Endothelial-to-mesenchymal transition (EndoMT) is a transdifferentiation by which endothelial cells (ECs) lose their specific morphology/markers and acquire myofibroblast-like features. Here, we ...

If tissue damage is severe, myofibroblasts migrate to the sites of the defect. This migratory function, the ability to contract the wound area and the production of extracellular matrix (ECM) by ...

Moreover, our data revealed novel mechanistic aspects of TGF-β in the Wnt-dependent myofibroblast differentiation pathway. A better understanding of the nature of inflammatory progenitors and the ...

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

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Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in bone biology and hematopoiesis, respectively. The role of ...

1 State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Organ Fibrosis, College of ...

Dr. Answorth A. Allen is the Associate Surgeon-in-Chief and Deputy Medical Director at HSS where his responsibilities encompass a wide array of roles in the field of orthopedic surgery. In this ...