如今，癌症的休眠和复发依然是癌症生物学研究领域的一大谜题，由于癌症局部和全身性的复发被认为是由起源于淋巴 血管 肿瘤栓塞的休眠微转移所引起的，于是研究人员就想知道是否癌症的休眠过程是否是从淋巴血管的栓塞内开始的。

mTOR and tyrosine kinase inhibitors may play an increasing role in the management of well-differentiated neuroendocrine tumors in the future. Peptide receptor radiotherapy is a new treatment ...

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...

Using breast cancer patient-derived organoids and tumor ... Key changes include reduced activity of mTOR, a metabolic regulator, and structural shifts in E-cadherin, a molecule involved in cell ...

Celcuity's lead asset, Gedatolisib, is a dual PI3K/mTOR inhibitor targeting various cancers, currently in multiple Phase 3 ...

Our research group is interested in understanding, at the structural and mechanistic levels, the maintenance of genomic integrity and the control of cell growth, both of which figure prominently in ...

Using breast cancer patient-derived organoids and tumor ... Key changes include reduced activity of mTOR, a metabolic regulator, and structural shifts in E-cadherin, a molecule involved in cell ...

Periodically abstaining from food helps intestinal stem cells regenerate and heal from injuries—but also increases cancer ...

More information: Xiaonan Xu et al, PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis, Cancer Research (2024). DOI: 10.1158/0008-5472.CAN-23 ...