ERK inhibition prevented irinotecan-induced pro-inflammatory gene expression but had only a slight effect on lipid accumulation. However, irinotecan also induced an impairment of the autophagic flux ...

In this process, the autophagic cargo receptors SQSTM1/p62 and NBR1 drive cargo condensation, while TAX1BP1, which binds to NBR1, recruits the autophagy machinery to facilitate autophagosome ...

Based on these results, we propose a dynamic liquid-like, rather than a stoichiometric, model of autophagy adaptors to explain the interactions between autophagic membranes (i.e., ATG9 vesicles and ...

Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key ...

Not only have researchers identified how a common cellular protein affects aging, but they’ve tweaked the genes that produce ...

Because nitrogen fertilizers contribute to global greenhouse gas emissions, scientists are looking for ways to modify ...

近日，卢曾军教授课题组在《PLOS PATHOGENS》期刊上发表了题为“Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the ...

Heat shock protein 90 (HSP90) is a molecular chaperone that promotes the proper folding and stability of several oncogenic ...

Mitophagy, a specialized autophagic process, is essential for maintaining mitochondrial quality control by selectively degrading damaged mitochondria. This process is crucial for cellular functions ...

There was also a reduction in myocardial cell disarray and a visible reduction in autophagic vacuoles, a hallmark of the disease. The company also noted stabilisation of three other measures – a ...

All cells are encapsulated by a membrane of complex lipidic composition, and understanding the roles of different lipids in membrane function is experimentally challenging to address. Here ...

This useful study examines the function of the rnc gene, which encodes the RNase III ribonuclease, as it relates to virulence of Salmonella Enteritidis. The authors demonstrate that the rnc gene is ...