These three newest antitubercular compounds belong to newly exploited chemical classes. This is most striking in the work of Andries and colleagues 3. They synthesized a library of diarylquinoline ...

本文翻译整理：FIM青年编委骆骄阳（中国医学科学院药用植物研究所）点击查看原文研究背景和意义结核病目前仍然是一个全球性的健康问题，其治疗通常涉及一线抗结核药物。但由于相关的肝毒性风险易导致不依从和耐药性，药物性肝毒性的发生率因地域不同各异。而大部分流行病学研究报告主要分布在欧洲、亚洲和美国，与发达国家 ...

The ability of bacteria to control the biophysical properties of their membrane phospholipids allows them to thrive in a wide range of physical environments. Fatty acid biosynthesis is an energy ...

Currently, a randomized trial is being conducted in Vietnam comparing a standard antitubercular treatment regimen with intensified treatment, in which patients receive a high dose of rifampicin ...

Sputum-based diagnostics have held centre stage over the past century but recent detection of TB-causing bacteria in people’s ...

7 Drug-induced hypersensitivity myocarditis is a rare but recognised adverse reaction to medications. However, current literature lacks documented cases of antitubercular drugs causing ...

Furthermore, substance abuse, including alcohol and narcotics, can damage the immune system and increase the risk of acquiring tuberculosis.” Dr Deepak Prajapat informed, “Antitubercular medicines, or ...

In 1955, Squibb received one of the most respected science prizes in the world, the Lasker Award, for its work discovering the antitubercular properties of Nydrazid (isoniazid), an antibiotic used ...

Along with its support of alpibectir, the pharma group is also running trials of another novel antitubercular drug, an inhibitor of the bacterial enzyme leucyl t-RNA synthetase (LeuRS), codenamed ...

(2015). "Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds." PLoS ONE10(10): e0138976. Lawson AP, Long MJ, Coffey RT, Qian Y, Weerapana E, El Oualid ...