uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

meduniwien.ac.at The phosphatidylinositol-3 kinases (PI3Ks) and the mammalian target of rapamycin (mTOR) pathway have long been recognised as critically regulating metabolism, growth or survival.

MC-II samples showed activations of CDK2, CDK1, AURKA, TTK, CDK6, and CHUK. MC-III samples exhibited activations of AKT1, AKT3, RPS6KB1, CSNK2A1, and PAK2. Finally, CDK2 and ROCK1 were activated in MC ...