The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...
mTOR kinase structure, mechanism and regulation ... (2017). Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature. 2017;552:368-373. Wang R, Wang S, Dhar A, Peralta C, Pavletich NP.