The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...
2018年1月19日,南方医科大学萍乡医院 (萍乡市人民医院)泌尿外科在Medical Science Monitor (中科院四区 IF=2.2)期刊上在线发表题为 "GP73 promotes invasion and metastasis of bladder cancer by regulating the epithelial-mesenchymal transition through ...
Charles Sawyers and colleagues have conducted a small early-stage clinical study to assess target modulation by the small-molecule inhibitor rapamycin. Rapamycin is approved to treat renal cancer ...
The second mTOR complex, mTORC2, contains mTOR, mLST8, and several unique proteins, including rictor (rapamycin-insensitive companion of mTOR). Rapamycin and its analogues do not bind directly to ...