The purine/purinergic system has emerged as a fundamental regulator of cellular communication, influencing various physiological processes such as metabolism, energy balance, and signal transduction.

Serine is an essential component of purine and pyrimidine biosynthesis ... For injuries and illnesses of the nervous system, it might act as a neuroprotective agent. Changes in serine metabolism have ...

Contrary to the belief that the path to sustainable development is increasingly out of reach, the results show that humankind has a variety of pathways to depart from its current unsustainable ...

The present Research Topic on the pharmacology and molecular pathways of micronutrients provides fresh insights from animal models and human studies regarding several mechanistic aspects of ...

The nervous system perceives both environmental stress and internal stimuli and coordinates a range of physiological processes, such as aging and metabolism. When neurons detect mitochondrial ...

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We found that the amino acid glutamine is required to activate the mevalonate pathway. Glutamine starvation inhibited cholesterol synthesis and blocked transcription of the mevalonate pathway—even in ...