Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite ...

This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...

Although it is well established that proteoglycans are required for FGF signalling, it was not known whether cells can regulate proteoglycan synthesis through glucose metabolism as a strategy to ...

Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

信号传导所需的蛋白聚糖（proteoglycan）的形成。这种信号传导对细胞分化和原始条纹（primitive streak）延伸至关重要。这种结构最终形成神经板 ...

Objectives: To determine whether joints affected by gout are also affected by osteoarthritis (OA). Methods: A postal questionnaire was sent to all adults aged over 30 years registered with two general ...

1 Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands 2 Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands 3 Institute of Anatomy ...