Membrane lipids, once simply regarded as the constituents of a passive barrier, are now increasingly appreciated as playing critical roles in conveying signals to the cell interior. Of particular ...

研究人员发现其具有一种意料之外的效应，能够增强对许多不同肿瘤的免疫反应。 Ali等人在本期的Nature杂志上指出，为了躲避免疫应答，肿瘤需要胞内激酶PI(3)K（phosphoinositide-3-OH kinase δ）的作用。研究显示，抑制这种酶能够解放受到抑制的免疫应答，增强机体 ...

The most important takeaway from the study is that these data suggest that CD47 is an attractive target for drug development.

When leptin binds to its receptors in these cells, it modulates insulin secretion by influencing pathways like ...

(IGF1, insulin-like growth factor 1; MAPKAP-K1, mitogen-activated protein kinase (MAPK)-activated protein kinase 1; PDK1, 3-phosphoinositide-dependent protein kinase 1; PKB/AKT, protein kinase B ...

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...

Each year there are extensive losses in crop productivity caused by abiotic stresses. Limited tolerance to extremes in temperatures, drought, salinity and nutrient imbalances have traditionally ...

Analysts at HC Wainwright cut their FY2027 earnings per share (EPS) estimates for shares of Pharming Group in a research note ...

The combined company will focus on advancing OnKure’s pipeline candidates targeting oncogenic mutations in phosphoinositide 3 ...

Draft guidance consultation NICE guideline 28 November 2024 Fenfluramine for treating seizures associated with Lennox–Gastaut syndrome in people 2 years and over [ID1651] Draft guidance Technology ...

Draft guidance consultation NICE guideline 28 November 2024 Fenfluramine for treating seizures associated with Lennox–Gastaut syndrome in people 2 years and over [ID1651] Draft guidance Technology ...