The third symptom cluster consisted of dyspnea symptoms, including dyspnea, dyspnea on exertion, fatigue, orthopnea, and paroxysmal nocturnal dyspnea. Between the three symptom clusters, age was ...

She denied fevers, chest pain, claudication, syncope, orthopnoea or paroxysmal nocturnal dyspnoea. She had an active history of tobacco use (20 pack-years) but no alcohol or illicit substance ...

When you lie down, fluid accumulation in the lungs signals the body to wake up to prevent asphyxiation. This phenomenon is called paroxysmal nocturnal dyspnea. It is not uncommon for people to wake up ...

whether you’ve had any exertional dyspnea, swelling of your ankles, PND (Paroxysmal Nocturnal Dyspnea), palpitations or checks your pulse and listens to your heart sounds for no apparent reason. Your ...

Nocturnal acid breakthrough is defined as the presence of intragastric pH < 4 during the overnight period for at least 60 continuous minutes in patients taking a proton-pump inhibitor (PPI ...

There is a simple discount patient access scheme for danicopan. NHS organisations can get details on the Commercial Access and Pricing (CAP) Portal. Non-NHS organisations can contact ...

The treatment of paroxysmal nocturnal hemoglobinuria (PNH) is advancing with proximal complement inhibitors ... Patient A’s hemoglobin plummeted to 7 g/dL, causing profound fatigue and dyspnea, while ...

Danicopan (Voydeya, Alexion) is indicated as 'an add-on to ravulizumab or eculizumab for the treatment of adult patients with paroxysmal nocturnal haemoglobinuria (PNH) who have residual haemolytic ...

HF was defined according to the criteria established by the European Society of Cardiology (ESC), which include: (1) the presence of symptoms and/or signs of HF such as breathlessness, orthopnoea, ...

with data in key settings including chronic lymphocytic leukemia (CLL), multiple myeloma (MM), paroxysmal nocturnal hemoglobinuria (PNH) and other hematologic diseases. Anas Younes, Senior Vice ...