uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

This study demonstrated that EPO enhanced osteoclast differentiation and bone resorption in vitro. We showed that EPO promoted osteoclast formation by up-regulating PPARγ expression through activating ...

Mechanistically, 4-PBA reduced the expression of ICAM-1 (intercellular adhesion molecule 1) via reducing peroxisome stress and attenuating SYK (spleen tyrosine kinase)-mTOR (mammalian target of ...

This study provides useful data substantiating a role of long noncoding RNAs in liver metabolism and organismal physiology. With murine knockout and knockin models, the authors invoke a previously ...

This study provides useful evidence substantiating a role for long noncoding RNAs in liver metabolism and organismal physiology. Using murine knockout and knock-in models, the authors invoke a ...

Oxidative stress and the accompanying chronic inflammation constitute an important metabolic problem that may lead to pathology, especially when the body is exposed to physicochemical and biological ...

A Marine Terpenoid, Heteronemin, Induces Both the Apoptosis and Ferroptosis of Hepatocellular Carcinoma Cells and Involves the ROS and MAPK Pathways.

ALI是一种伴有急性肺组织免疫炎症性反应的高死亡率呼吸系统疾病，发病急、病死率高[14]。诱发ALI的肺内因素是重症肺炎、溺水、肺挫伤等，肺外因素包括脓毒症、急性胰腺炎、VP等[15-16]。研究发现香烟烟雾产生的脂多糖可致肺损伤[17]。庄宛滢等[18]认为肺损伤 ...

2023a). It has been found that PF can be alleviated by molecular hydrogen, which is conducive to eliminating intracellular ROS and inhibiting the PTEN/AKT/mTOR signaling pathway (Lu et al., 2020).