Penn Ovarian Cancer Research Center and Basser Center for BRCA, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States ...
POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.
"Together, these results suggest that microglia are being activated by human neuron–produced APOE4 and, in turn, are potentially helping form the misfolded protein aggregates we see in Alzheimer's," ...