Introduction: Depression is a common psychological disorder, accompanied by a disturbance of the gut microbiota and its metabolites. Recently, microbiota-derived tryptophan metabolism and AMPK/mTOR ...

However, its exact molecular mechanism of action remains unknown. Our aim was to prove melatonin's short‐ and long‐term neuroprotection and investigate its role on the AMPK (AMP‐activated protein ...

Anjali Mukerjee then explains the key aspects of how to live longer. In the video, she outlines three main longevity ...

Furthermore, we show that regulation of ULK1/adenosine monophosphate-activated protein kinase (AMPK) signalling pathway by mTOR may in part be responsible for regulating autophagy signalling and the ...

Further analyses suggested that DBT reduces ubiquitinated proteins by promoting autophagy. Mechanistic studies indicated that DBT loss promotes autophagy via AMPK and its downstream ULK and mTOR ...

Pacylex was recognized as BioAlberta's 2024 Company of the Year. The award acknowledges a company that has shown significant achievement within the marketplace and Alberta's business community through ...

Semaglutide injections effectively support weight loss by regulating appetite and glucose levels, offering benefits for ...

Development of therapies that specifically target the AMPK–HNF4α–WNT signal cascade would probably represent effective ... cPARP, t-caspase 3, c-caspace 3), t-mTOR, p-mTOR (Ser 2448 and Ser2481), ...