The TT genotype appears to predispose to CRC that is MSI+. This may reflect the involvement of aberrant DNA methylation frequently associated with MSI+. The 844ins68 CBS polymorphism may protect ...

mcgill.ca Background: Clinical studies suggest that mild methylenetetrahydrofolate reductase (MTHFR) deficiency and high dietary folate may reduce the risk for colorectal cancer. There is concern, ...

Although no specific data to support pharmacogenetic-related birth defects were found for the NSAIDs, paroxetine and fluoxetine, it might be expected that polymorphisms modify their teratogenic ...

TT genotype of the methylenetetrahydrofolate reductase C677T polymorphism is an important determinant for homocysteine levels in multi-ethnic Malaysian ischaemic stroke patients[J]．Ann Acad Med ...

The 3 Hydroxy 3 Methylglutaryl Coenzyme A Reductase pipeline drugs market research report outlays comprehensive information on the 3 Hydroxy 3 Methylglutaryl Coenzyme A Reductase targeted therapeutics ...

Polymorphisms in genes encoding proteins in two major cellular pathways influenced by MTX, namely the folate and adenosine pathways, and their association with response to MTX have been examined ...

Inborn errors of metabolism (IEMs) are genetic disorders characterized by dysfunction of an enzyme or other protein involved in cellular metabolism. In most cases, IEMs involve the nervous system.

Numerous prior studies have indicated that the T allele genotype at the C677T site of the MTHFR gene increases hyperuricemia risk by elevating plasma homocysteine levels. Similarly, the ABCG2 gene, ...

DR. RICHARD R GOLDSCHMIDT has discussed the origin of miltery in a paper entitled ‘Mimic Polymomlrasm, a Controversial Chapter of Darwinism (Quart. Rev. Biol., 20; June pt., 194 ff As he rightly ...

The affected gene in type 2 inherited methemoglobinemia leads to a problem with a protein (called cytochrome 5 reductase). This protein helps keep the iron in the right configuration for regular ...