However, it is clear that repeat TGN measurements are required for an unambiguous index of active metabolite exposure. In view of the high intrapatient variability in TGN production over time, TGN ...
Ground-breaking investigation leverages Metabolon's Global Discovery Panel for metabolite genome-wide association study (MGWAS) for cerebrospinal fluid (CSF) and brain metabolite levels as they ...
per kgm. has been shown to produce 5-ethyl-5-(3-hydroxy-3-methylbutyl) barbituric acid as the main metabolite, about 67 per cent of the original dose being excreted in this form 1.
An exploratory study conducted at the University of Eastern Finland has examined metabolomic patterns associated with psychotic-like experiences in ...