Drug Discovery faces a rising number of projects that demand the generation of cellular reagents with controlled or lower target protein expression. Here, we have tested and optimized several ...
However, the detailed structural and molecular understanding underlying lipid membrane modification during pathogenic invasion remains unclear. In this study, we show that a specific Leishmania ...
The study highlighted the importance of membrane mechanics to the supercomplex formation and revealed differences in structural and dynamical features of the protein components upon complex formation.
(2) The analysis of the bilayer deformation lacks membrane mechanical expertise. Here I am not ridiculing the authors - the presentation is very conservative: they find a deformed bilayer, do not say ...
In recent years, antibody therapies have seen rapid advancements, becoming pivotal treatments for cancer, infectious diseases, and autoimmune disorders. Innovations such as monoclonal antibodies (mAbs ...