Many genes whose expression is restricted to neurons in the brain contain a silencer element (RE1/NRSE) that limits transcription in nonneuronal cells by binding the transcription factor REST ...

Background: Histone deacetylases (HDACs) -2 and -6 are localized in the nucleus and cytoplasm of cells and have been implicated in the development of left ventricular (LV) hypertrophy, cardiac ...

What role do histone modification enzymes play in cancer progression and therapy resistance? Studying enzymes such as histone acetyltransferases (HATs), histone deacetylases (HDACs), and histone ...

Various genetic modifications including BRAF mutations, RAS mutations, RET mutations, paired-box gene 8/peroxisome proliferator-activated receptor-gamma fusion oncogene, RET/PTC rearrangements, ...

The dysregulated post-translational modification of proteins is an established hallmark of human disease. Through Zn 2+-dependent hydrolysis of acyl-lysine modifications, histone deacetylases (HDACs) ...

gene-expression profiling studies revealed the aberrant expression of products that may provide the rationale for the unprecedented usage of drugs such as tyrosine kinase inhibitors and histone ...

The term "alert and oriented" (AO) is a medical notation describing a person's level of consciousness and cognition (the ability to understand and learn through thought, experiences, and the senses).

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The use of "anno domini" and "before Christ" to mark time began in the early days of Christianity, and they're still used to track calendar years today. When reading historical texts or delving ...

When students become active doers of mathematics, the greatest gains of their mathematical thinking can be realized. The process of sense making begins when we create classrooms full of curious ...