The nucleus is the double membrane limited structure within an eukaryotic cell that contains the chromosomes, and where the DNA is replicated or transcribed into RNA. The membrane is perforated by ...

Conclusion Our immunoepigenetic strategy harnesses IFNγ-mediated network to augment the cancer-immunity cycle, revealing a self-reinforcing STAT1-GSDME pyroptotic circuitry as the mechanistic basis ...

Nucleus RadioPharma, co-founded by Mayo Clinic, plans to build facilities in Mesa, Arizona and Springhouse, Pennsylvania. The start-up is also creating a manufacturing center in downtown Rochester ...

Two years after emerging with its initial funding round, CDMO Nucleus RadioPharma is going bicoastal, revealing expansions at two sites that the company believes will "significantly improve ...

For many years, scientists believed that fundamental particles like protons and neutrons that form an atomic nucleus, can’t be divided further into smaller units. However, in the following years ...

This view of the atomic nucleus changed when James Chadwick discovered the existence of the neutron in 1932, for which he won the Nobel Prize three years later. Not too long afterward, scientists ...

Given recent evidence that pyroptosis, as a new form of programmed cell death, is induced by caspase-3-dependent GSDME (gasdermin E) cleavage, we hypothesized that cathepsin L might promote PH through ...

The temporary pair of correlated nucleons is highlighted in purple. The atomic nucleus is made up of protons and neutrons, particles that exist through the interaction of quarks bonded by gluons.

For example, quercetin induces pyroptosis in gastric cancer cells by increasing the expression of pyroptosis markers such as GSDMD, GSDME, and NLRP3 in a concentration-dependent manner (Rong et al., ...