New Delhi: Reviewing the Phase III clinical trial protocol of the GZ402671 (Venglustat) presented by the pharma major Sanofi, ...

As per the National Gaucher Foundation, this disease was first discovered by a French doctor, Philippe Gaucher, after whom it ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

We can give a patient blood transfusions to alleviate the fatigue and anemia associated with the disease, but we seek more definitive treatments like recombinant glucocerebrosidase that replaces the ...

The changes in glucocerebrosidase activity, biochemical ... resulting in neuronopathic GD (nGD).1 2 Enzyme replacement therapy (ERT) and substrate reduction therapy (SRT) could achieve significant ...

Gaucher disease is caused by an inherited defect in an enzyme that the body uses to break down a fatty substance called glucocerebroside. When this substance is not broken down, it accumulates in the ...