南非国家健康研究伦理委员会负责起草该指南，南非卫生部则发布了修订后的指南。目前尚不清楚该指南在多大程度上采纳了南非科学界的意见。目前，全球没有一个国家明确允许在临床环境中进行可遗传人类基因组编辑。

《自然》杂志要求南非卫生部和国家卫生研究伦理委员会发表评论。南非卫生部发布了修订后的指导方针，而国家卫生研究伦理委员会是国家卫生法下的一个法定机构，起草了这些指导方针。到本文发表时，尚未收到任何评论。

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