First human trial of stem-cell-derived corneal transplants for LSCD shows vision improvement, suggesting a safe and effective ...

with structural changes in the cytoskeleton potentially influencing the progression of organ fibrosis. This review examines cytoskeletal remodeling and its impact on the transformation or activation ...

MNKD-201, an inhaled formulation of nintedanib for IPF, was shown to be safe and well tolerated in a clinical trial with ...

Moreover, pharmacological inhibition of PGC-1α by SR18292 induced regression of pre-established, bleomycin-induced skin fibrosis. Conclusion PGC-1α is upregulated in SSc and promotes autophagy to ...

Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...

Without them, the integrity and transparency of the corneal surface becomes compromised, leading to fibrotic tissue buildup, and ultimately, vision loss. Traditional treatments often involve ...

However, research at Cedars-Sinai in Los Angeles may offer patients a glimmer of hope. Scientists there say they've ...

Discover how cutting-edge research unveiled at ACR Convergence 2024 highlights macrophage-fibroblast interactions and the ...

Fibrosis, or scarring, plays a major role in many diseases and is often accompanied by inflammation. Pulmonary fibrosis refers to scarring in the lungs, which damages lung tissue, making it harder for ...

The EFTISARC-NEO trial, with a data cut-off of 20 October 2024, also showed 71.4% of patients achieved a pathologic response ...