The activated cGAS-STING pathway promotes fibroblast proliferation and excessive collagen deposition by releasing inflammatory factors, resulting in lung tissue fibrosis and further damage to the ...

aDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States bRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 ...

The research focuses on “cellular senescence,” a process where cells stop dividing and enter a state associated ... This discovery was made using advanced sequencing and bioinformatics analyses on ...

The primary pathological features of fibrotic diseases include recurrent damage to normal cells and the abnormal activation of fibroblasts, leading to excessive deposition of extracellular matrix and ...