Endoplasmic reticulum model brings new insight to cell organelle's structure and function
The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in ...
Nature8 天
Signal integration in the endoplasmic reticulum unfolded protein response
The endoplasmic reticulum (ER)-localized transmembrane proteins IRE1, PERK and ATF6 detect the load of unfolded protein in the lumen of the organelle, serving as stress receptors. They transduce ...
Nature1 年
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Perturbations of the endoplasmic reticulum (ER) caused by accumulation of unfolded proteins in this organelle trigger signal-transduction responses that assist with restoration of homeostasis ...
The EMBO Journal6 天
Making contact away from home: a bacterial secreted effector mediates inter-organelle ...
Inter-organelle communication via the formation of membrane contact sites (MCS) is essential for cell homeostasis. Bacterial pathogens residing in membrane bound vacuoles have exploited this ...
EurekAlert!14 天
Spirited away: Key protein aids transport within plant cells
The KNS3-KNSTH1-KNSTH2 complex acts as a cargo receptor for the transport of boric acid channels from the endoplasmic ...
Baylor College of Medicine3 年
Project 3: Targeting Endoplasmic Reticulum Stress Sensor IRE1 to Enhance Chemotherapy ...
We have identified the IRE1/XBP1 branch of the Unfolded Protein Response (UPR) or endoplasmic reticulum (EnR) stress response as a previously unexplored therapeutic vulnerability in MYC-driven breast ...