▲ 点击上方蓝字关注CellPress细胞科学 ▲生命科学Life science近日，西湖大学吴连锋教授和哈佛医学院Alex Soukas教授在Cell Press细胞出版社旗下期刊Trends in Endocrinology & ...

For other drugs, such as dihydrofolate reductase inhibitors, overexpression of their target predicts resistance. Other potential drug targets are overexpressed in many types of cancer, but this ...

The authors initially noted an unexpected difference in the ability of tight-binding ligands to impair the degradation of the enzyme dihydrofolate reductase (DHFR) or of the ribonuclease barnase ...

Here, we report the all-atom conformational transition paths of three protein systems constructed using the ABPO methodology. Two systems, triose phosphate isomerase and dihydrofolate reductase, ...

A new study published in the Journal of the European Academy of Dermatology and Venereology found that methotrexate (MTX) has ...

This important study explores the interplay between gene dosage and gene mutations in the evolution of antibiotic resistance. The authors provide solid evidence to connect proteostasis with gene ...

Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. 1 DS tab, 2 regular tabs ...

Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is stronger for the ...

Summary and Introduction Clinical Application—Disease Entities Theoretical Framework for Therapy−The 'Steel Paradigm' Conclusion References Theoretical Framework for Therapy−The 'Steel ...

254. Schreiber S, Jose J (2024) FRET measurements in living bacteria for interaction studies of BamA with BamD and inhibitor identification. Cells, accepted 253. Wojciechowski M, Jokiel J, Kuss H, ...