This important work advances our understanding of DNA methylation and its consequences for susceptibility to DNA damage. This work presents evidence that DNA methylation can accentuate the genomic ...

A Seattle biotech company is working on a tweak to gene expression that could shut down hepatitis B (HBV), one of the viruses ...

Plasma samples were assessed for NET markers, including cell-free DNA (cfDNA) and histone-DNA complexes, along with DNase ...

Her group investigates chromatin dynamics during DNA replication and repair. The Mattiroli group uses biochemical reconstitutions, structural approaches and cell biology to elucidate the biophysical ...

Researchers from the Mattiroli group have found that the way DNA is packaged in cells can directly impact how fast DNA itself is copied during cell division. They discovered that DNA packaging sends ...

Portal vein thrombosis (PVT) is a challenging complication in liver cirrhosis, with no currently available sensitive ...

The histone proteins of complex cells are named H2A, H2B, H3 and H4. They are assembled into groups of eight, around which a ...

The good news is that drugs called CHK1 inhibitors were found to selectively destroy tumor cells containing ecDNA in mice ...

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.

Cancer continues to be one of the most challenging diseases due to the complex molecular mechanisms involved. Epigenetic modifications, particularly histone modifications, play a crucial role in ...

Lytic induction therapy has been developed to selectively kill EBV-positive cancer cells by triggering viral reactivation ...

In conclusion, this intriguing report builds on the work of many other groups by further unraveling MECP2 function in the ...