Circulating tumor cell formation at the primary tumor site and EMT. (Top) Heterotypic interactions between the stroma and cancer cells at the primary tumor site in carcinomas lead to EMT ...

However, breast cancer cells show a complex pattern ... The highest incidence of these cells in MBC patients supports the idea that EMT contributes to the metastatic potential of CTCs.

Comparison of circulating tumor cell numbers before and after ... of CTCs might be downregulated in the course of epithelial-mesenchymal transition, thus probably affecting tumor cells with ...

The developmental program Epithelial-Mesenchymal Transition (EMT) is frequently re-activated in metastatic and recurrent ... we developed the “NanoFlare” method that enables the detection and ...

Furthermore, researchers have observed that the two cell populations have very different locations within the tumor. The cells that activate the embryonic-like EMT process are found in the ...

Image of a mouse breast tumor showing the segregation of both cell populations: The cells that activate the EMT process to ...