Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune ...

发现PLPP1敲除的CD8 + T细胞不饱和磷脂合成代谢增加，最终导致细胞发生铁死亡，降低其抗肿瘤功能。过表达PLPP1能够增强CAR-T细胞的磷脂代谢 ...

在这项临床研究中，来自北美、欧洲和日本 31 个医疗中心的 130 名复发的滤泡性淋巴瘤患者在两年的时间里接受了一种 CAR-T ... METRNL是CD8+T细胞代谢 ...

A new bioprocessing technique developed by a team of researchers could improve a range of therapies based on CAR-T cells.

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune ...

OV-CD19T和CD19-CAR-T联合治疗在体外和体内都是一种安全有效的治疗实体瘤的方法，提示具有持久的肿瘤杀伤作用。 癌症免疫疫苗 含有TAAs或肿瘤特异性抗原（TSA）的治疗性癌症疫苗可直接刺激免疫系统，激活CD4+和CD8+T细胞以杀死肿瘤。已经开发出许多癌症疫苗 ...

Chimeric antigen receptor T-cell therapy, or CAR-T cell therapy, is one type of immunotherapy. Sometimes likened to a "smart drug" or "living drug," CAR-T cell therapy relies on genetically ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

Chimeric antigen receptor (CAR) T cell therapy is an immunotherapy. It uses a patient’s own immune system to fight certain blood cancers. Normal T cells can “hook” onto cancer cells and kill them, but ...

Haroun stated“This theory is supported by the inhibitory activity of DeltaRex-G in transduced CD4+ CD8+ cell cultures. DeltaRex-G may be used to treat CRS by inhibiting a certain proportion of the ...

In CAR T cell therapy development, antibody-coated magnetic beads enable a one-step process for cell isolation and activation, allowing clinical-scale dose production in just 2 to 3 weeks. Despite ...