Ovarian tumors are infiltrated by both effector (CD4+CD25-) T cells and by an excess of TREG cells (CD4+CD25+). These TREG cells impede the function of the effectors in combating the tumor.

New research shows that blood-based immunophenotyping can enhance rheumatoid arthritis treatment by identifying immune ...

Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for ...

Surface proteins and cytokines of lung T cells were analyzed by flow cytometry using antibodies against CD3 ... These results indicate that chronic tobacco stimulation primarily leads to increased ...

Here, using overlapping synthetic peptides, we screened the dominant epitopes of Th1 responses in mice post-vaccination with different adjuvants and found that the adjuvants altered the ...

这类PD1 + TCF + CD4 + T细胞虽然原本可以向效应T细胞等不同方向分化，但在同为CD4 + T细胞的Tregs约束下，它们分化产生的基本只能是Tregs；只有当Tregs被 ...

These have shown strong antitumour activity, which has been largely associated with increased effector activity of CD4 + and/or CD8 + T cells, as well as NK and NKT cells. Interactions that occur ...