Early mitotic degradation of Nek2a and cyclin A2 may therefore explain why only separase, but not Wapl, can trigger anaphase.

Exquisite insight into chromosome separation reveals the intricate relationships between molecular changes and large-scale ...

Abstract: The proper control of mitosis depends on the ubiquitin-mediated degradation of the right mitotic regulator at the right time. This is effected by the Anaphase Promoting Complex/Cyclosome ...

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The density reaches a maximum in late mitosis (anaphase), when mitotic chromosomes are most condensed. A team of scientists studying cell division developed a special light microscopy system and ...

Nucleosomes were most constrained when chromosomes were being moved to opposite poles of the cell during anaphase, a specific phase of cell division. These constraints were loosened during ...

Nara Institute of Science and Technology, Japan Tokyo Institute of Technology, Japan The University of Tokyo, Japan Chubu University, Japan The University of Tokyo Graduate School of Science, Japan ...