Metabolic alterations in cancer cells are numerous and include aerobic glycolysis, reduced oxidative phosphorylation and the increased generation of biosynthetic intermediates needed for cell ...

Investigations of PI3K and its downstream effects on Akt have confirmed that these oncogenes play a direct role in stimulating cellular glucose uptake and in directing the metabolic conversion to ...

Once generated, pyruvate can enter the mitochondria to fuel aerobic metabolism or it can ... like increased glycolysis, provides an energetic lifeline to the cell. What do these results teach ...