Mechanistically, metformin treatment upregulated p-AMPK (phosphorylated AMP-activated protein kinase) and downregulated p-STAT3 (phosphorylated signal transducer and activator of transcription 3) ...

Perturbation experiments in GC tumour cell lines and xenograft models further demonstrated that HNF4α is downregulated by AMPKα signalling and the AMPK agonist metformin; blockade of HNF4α activity ...

Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China ...

People living with type 2 diabetes may know all about metformin, which is an oral medication taken to manage this health condition. This medicine works by lowering blood sugar levels, improving ...

Sherrol Reynolds, OD, FAAO, FNAP, explores the role of metformin — a drug conventionally used for treating diabetes — as a preventative strategy for limiting age-related macular degeneration risk, and ...

Get detailed information on Metformin, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it. The updated prescription ...

The team conducted the study on mice and administered a combination of three different drugs (a growth hormone, Metformin, and an AMPK enzyme-activating drug). What they discovered was ...

LOS ANGELES — Metformin prescribed within a week of SARS-CoV-2 infection was associated with a 53% reduction in long COVID or death over 6 months in people without diabetes or prediabetes ...

Using these organoids, they tested both metformin and imatinib, a drug already approved for DFSP treatment. Their study revealed that, beyond inhibiting tumor growth, metformin uniquely impacted ...