Perturbation experiments in GC tumour cell lines and xenograft models further demonstrated that HNF4α is downregulated by AMPKα signalling and the AMPK agonist metformin; blockade of HNF4α activity ...

Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China ...

Advances in multi-omics, artificial intelligence (AI), deep learning (DL), ageing biomarkers, precision imaging, ageing clocks, robotics, and smart technologies have enabled researchers to ...

【导读】本研究旨在探讨联合使用二甲双胍和辛伐他汀疗法对脑胶质瘤恶性进展的抑制作用。11月9日，中国科学技术大学研究团队在期刊《Cell Death&Disease》上发表了研究论文，题为“Combined metformin and ...

A genetic regulator of tomato sweetness has been identified through comparison of wild and domesticated varieties of the plant. Genetically engineering tomatoes to alter this gene increases sugar ...

Hydroxytyrosol produced by engineered Escherichia coli strains activates Nrf2/HO-1 pathway: An in vitro and in vivo study.