AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic ...

The processing of self-peptides in TECs depends on bulk protein degradation systems, specifically autophagy and proteasomes. Studies using autophagy- and proteasome-deficient mouse models have ...

Furthermore, we show that regulation of ULK1/adenosine monophosphate-activated protein kinase (AMPK) signalling pathway by mTOR may in part be responsible for regulating autophagy signalling and the ...

Mechanistically, metformin treatment upregulated p-AMPK (phosphorylated AMP-activated protein kinase) and downregulated p-STAT3 (phosphorylated signal transducer and activator of transcription 3) ...

Development of therapies that specifically target the AMPK–HNF4α–WNT signal cascade would probably represent effective ... Five GC cell lines (AGS, N87, NCC19, NCC59 and SNU1967) were grown under the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Autophagy mediates the degradation of harmful ...

With more thorough research in recent years, different types of cell death such as apoptosis, autophagy, necroptosis and ferroptosis have been clarified (1–3). This Research Topic compiles a range of ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mevalonate pathway produces essential ...

The main idea tested in this work is that host galectin-9 inhibits Mycobacterium tuberculosis (Mtb) growth by recognizing the Mtb cell wall component arabinogalactan (AG) and, as a result, disrupting ...