WHILE carrying out a study of hydroxyproline synthesis in biological media, by hydroxylation of proline or peptides containing proline, we have also investigated the possibility of hydroxylation ...

来源：BioSyn世纪论文的研究目标及其重要性本论文于2024年10月25日在线发表于JACS。旨在利用生物合成指导和修饰酶催化的方法,发现新的 dhilirane 型杂萜化合物 (DMs)。DMs 是一类罕见的真菌杂萜,具有独特的 ...

Pharmaceutical scientists from the National University of Singapore (NUS) have identified and characterized a unique ...

ARD proteins from both NFκB and Notch systems were found to compete with HIF-α for FIH-dependent hydroxylation and in most cases were actually better substrates than HIF-α in vitro. Structures ...

Pharmaceutical scientists from the National University of Singapore (NUS) have identified and characterized a unique ...

These enzymes are responsible for the first steps in the hydroxylation of cholesterol, leading to the formation of the furostanol-aglycone (16,22,26-trihydroxycholesterol), a key branching point ...

These enzymes are responsible for the first steps in the hydroxylation of cholesterol, leading to the formation of the furostanol-aglycone (16,22,26-trihydroxycholesterol), a key branching point ...

"Our protein interaction experiments showed that GAME15 interacts with the enzymes GAME6, GAME8 and GAME11. These enzymes are responsible for the first steps in the hydroxylation of cholesterol, ...

The goals of nutritional therapy are to improve PCM and correct nutrient deficiencies. This can be accomplished via oral, enteral, or parenteral methods, or a combination of these modalities ...