Through the transfer of a carbon atom to tetrahydrofolate, a reduced form of folic acid, it transforms the amino acid serine ...

High levels of MTHFD2 are needed to release formate from mitochondria, which is coupled to tetrahydrofolate by MTHFD1, to generate nucleotide precursors. One-carbon Therapeutics and its ...

Serine is the most common one-carbon unit used to produce S-adenosylmethionine through methylation. In tetrahydrofolate methylation processes, it provides a one-carbon unit. In addition to being a ...

This important study explores the interplay between gene dosage and gene mutations in the evolution of antibiotic resistance. The authors provide solid evidence to connect proteostasis with gene ...