Many of these new tetracycline derivatives would be very difficult or impossible to obtain through semisynthesis. These include analogs containing heterocyclic D rings, aryl substituents at the 6 ...
Cell Microbiol. 12: 1435-1445 (2010). Pentelute BL, Barker AP, Janowiak BE, Kent SB, Collier RJ., A semisynthesis platform for investigating structure-function relationships in the N-terminal domain ...