Many of these new tetracycline derivatives would be very difficult or impossible to obtain through semisynthesis. These include analogs containing heterocyclic D rings, aryl substituents at the 6 ...

Cytodata refers to a community of researchers and resources involved in the image-based profiling of biological phenotypes. These biological phenotypes are typically induced by genetic or chemical ...

ThiS is a sulfur carrier protein that plays a central role in thiamin biosynthesis in Escherichia coli. Here we report the solution NMR structure of ThiS, the first for this class of sulfur ...

Development of salicyl-AMS, a novel antibacterial agent to treat tuberculosis and other infections Louise and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer ...

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Monoubiquitination of histone H2B (H2B-Ub) plays a role in transcription and DNA replication, and is required for normal localization of the histone chaperone, FACT. In yeast, H2B-Ub is ...

Cell Microbiol. 12: 1435-1445 (2010). Pentelute BL, Barker AP, Janowiak BE, Kent SB, Collier RJ., A semisynthesis platform for investigating structure-function relationships in the N-terminal domain ...