Senescent cells can be observed in vivo in preneoplastic lesions. Collectively, mounting evidence indicates that senescence, triggered by different stimuli, is the outcome of a protracted DDR.

The particular aspect of these cases, in which the onset of a frank leukemia was preceded by a preneoplastic, hyporegenerative phase, may be better understood in the light of an investigation ...

CDK12 loss in the murine prostate epithelium led to preneoplastic prostate lesions with enhanced cellular proliferation and immune infiltration by T cells with elevated cytokine levels.