Researchers developed a highly selective fluorescent probe to image serotonin in cells and animal models, shedding light on ...

Constructing complex molecules from simpler ones is pivotal for the development of pharmaceuticals, materials science, and ...

Afterward, facilitated by proximity, a second bond is formed (nucleophilic reaction between an amino group in serotonin and a ...

Serotonin in depression is highly relevant in diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a fluorescent probe for imaging processes that is ...

"We also focused on cysteine because it's the most nucleophilic amino acid," says first author Evert Njomen, PhD, an HHMI Hanna H. Gray Fellow at Scripps Research and a postdoctoral research ...

Serotonin in depression is highly relevant in diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a fluorescent probe for imaging processes that is ...

To develop operationally straightforward and synthetically useful methods for the preparation of nitrogen containing compounds using simple ammonium salts with nucleophilic and non-nucleophilic ...

"We also focused on cysteine because it's the most nucleophilic amino acid," says first author Evert Njomen, Ph.D., an HHMI Hanna H. Gray Fellow at Scripps Research and a postdoctoral research ...

The most accepted model to explain this property of lentiviruses is that nucleophilic virion proteins chaperone viral nucleic acids across the nuclear envelope. A recent study by Zennou and ...

During this special 1.5 hour free interactive broadcast, you will discover examples of drugs and their mitochondrial targets as well as trapping methods using nucleophilic scavengers, such as GSH ...

MK-STYX is a novel protein included in the dual specificity mitogen-activated protein kinase phosphatase class that lacks the essential nucleophilic cysteine required for phosphatase activity.

For example, alcohols can undergo nucleophilic displacements of the hydroxyl functionality, carboxaldehydes can participate in condensations with primary amines to form enamines and carboxylic ...